BIO 1130 Lecture Notes - Lecture 3: Missense Mutation, Nonsense Mutation, Silent Mutation

• School: University of Ottawa
• Department: Biology
• Course: BIO 1130
• Professor: Gambarotta Sandro

Document Summary

Encoded in polynucleotide chains in a language with 4 letters. Each cell needs its own copy of dna. Each old strand is a template for the new strand. Higher in rna viruses (10-3 to 10-5 mutations base-1 generation-1) than in. Higher in mitochondrial dna (3x10-6 to 2. 7x10-5) than in genomic dna (2. 5x10-8) Higher in asexual species than sexual species. In humans ~1. 1x10-8 mutations, per site per generation. One gene can have many different sequences, depending on how we edit it. When a cell needs to replicate, unzip on a specific part of the double helix and use as the template. Rna peels off template, zipped back up and then rna is processed. The copy is then edited by selected removal or selected addition. Alternate mrna transcripts created by selective slicing/ arrangement of exons the gentic code has both specificially and redundancy. Gentic code was establiches very earlu in the evolution of life and has remained unchanged.