BPS 2110 Lecture Notes - Lecture 3: Rhabdomyolysis, Stereochemistry, Drug Metabolism

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Use of an available biological screen to discover a lead structure. Understanding the disease, developing a bio-assay and then screening a library of compounds for activity. Understanding cholesterol biosynthesis has led to the development of cholesterol lowering drugs called statins. Vital substituent of cell membranes, especially in the brain and spinal chord. Precursor to all steroid hormones including testosterone, estrogen, cortisone, and cortisol. Precursor to bile acids, which are crucial to digestion. Deposition in the arteries is associated with artherosclerosis and heart disease. Genetic disorder causing high cholesterol levels, in particular very high levels of ldl (bad cholesterol) in the blood. Due to mutation sin the gene that encodes for the ldl receptor protein that normally removes ldl from the circulation: causes plaque build up. People with one abnormal copy of the ldlr gene often have premature cardiovascular disease at the age of 30 to 40.

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