BPS 2110 Lecture Notes - Lecture 12: Vinblastine, Small Intestine, Topotecan
7 Nov 2017
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De ne concepts from the list of important concepts. Describe and compare the gastric and intestinal features that are susceptible to affect drug absorption. Write fick"s law equation for predicting the solubility rate of a solid drug product, and brie y explain the meaning of each component of the provided equation. List the main physicochemical factors affecting drug absorption. Use henderson-hasselbach equations to calculate the ionized/unionized ration of drugs at ph values corresponding to different parts of the gastrointestinal system. Describe four different experimental strategies to study drug permeability. Fick"s law for dissolution of a solid drug product. The fraction of an administered dose of unchanged drug that reaches the systemic circulation. Intravenous administration is considered as a top reference (100%) for drug absorption or bioavailability. The ability to go across a membrane or other barrier in a passive or active manner. Sometimes distinguished from permeability, the rst being a process and the second a constant.
