HSS 3106 Lecture Notes - Lecture 12: Progressive Muscle Relaxation, Muscle Relaxant, Noxious Stimulus

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Choosing appropriate anesthesia depend on: patients general physical condition, area being operated on, anticipated length of procedure: want amnesia, suppression of responses to noxious stimuli (analgesia), unconsciousness/anxiolysis, myorelaxation/immbolity, don"t want cardiovascular instability, excitation/convulsions, emesis, shivering. Adverse drug reactions older adults more likely to have adverse drug reactions than younger b/c they take more medications. Types of general anesthesia inhalation anesthetics volatile liquids or gases (no) i. e desflurane, nitrous oxide (laughing gas), sevoflurane intravenous anesthetics faster, less painful and more reliable than intramuscular subcutaneous injections i. e fentanyl, ketamine, propofol. Mechanism of action: enhanced gaba effect on gaba receptors most common, produce cns inhibition, others blockage of nicotinic receptor subtypes, inhibition of nmda (glutamate) receptors, enhancement of glycine effect (leading to immobility) Dangers of malignant hyperthermia life-threatening, acute pharmacogenetics disorder that develops during anesthesia rapid increase in body temp, unexplained tachycardia, unstable bp, muscle rigidity, and cyanosis.

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