ANT202H5 Lecture Notes - Lecture 8: Thrifty Phenotype, Low Birth Weight, Blood Sugar
Document Summary
Adaptation to energy variability: differences in how effectively our bodies process particular foods, digestive systems use food in different ways, adapting to local nutritional opportunities led to evolution of related genetic differences. High levels of insulin leads to insulin resistance: obesity & associated type 2 diabetes very common. Thrifty genes & type 2 diabetes: but not everyone eating calorie rich diet likely develop type 2 diabetes, difference in diet & activity patterns, eu lowest levels. Milk stimulates large rise in blood sugar level. Thrifty genes + milk = likely to develop diabetes & die prematurely. Genes eliminated from population: unlikely h/g subject to food shortages vs. agriculture. Thrifty phenotype hypothesis: developmental origins of health & disease hypothesis. Exposed to nutrient scarcity during fatal & infant stages of development. Thrifty mechanisms for nutrient uptake, retention & metabolism: abundant resources over sustained period.
