BIO200H5 Lecture Notes - Lecture 4: Peripheral Artery Disease, Angina Pectoris, Guanylyl Cyclase
Document Summary
* reason why more failures in phase 2: larger population size. * only about 25% of candidates from phase 2 will pass onto phase 3 failing isn"t always a bad thing! Because bvs are made of endothelium and muscle tissue. The smooth muscle tissue is involved in either dilating or constricting tissue. Normally, neurotransmitters will trigger dilations and relaxations. Endothelial cells make nitrous oxide (no): no enters smooth muscles and vasodilates them; the drug developers were interested in looking at this no pathway. The endothelial cell has enzyme called enos which synthesizes no in endothelial cells does this by converting amino acid arginine to. No: no then transports into the smooth muscle tissue thru passive diffusion. Some will diffuse into muscle; the rest will diffuse into the body: once it gets to smooth muscle cell, it doesn"t automatically vasodilate. It has to communicate with cell network, and does this by an enzyme, guanylate cyclase.
