BIO200H5 Lecture Notes - Lecture 17: Alpha-Amylase, Amylase, Starch
Document Summary
They won"t be in every single on our cells. More often than not, it"s located in a cell type that has irregular activity. A selection pressure is put on cells that have an increased resistance to drugs. More common polymorphism variation in copies of a single gene/nucleotide sequence. Structural variations in the genome: how it packs around histones, how it"s able to be accessed, how it coils etc. The number of repeats will vary in a population, which can lead to an increase in dna content (higher copy number) or decrease in dna content. You can have deletions of segments of dna, duplications, multiple-duplications, inversions. About 9=12% of our genomes are made of cnvs. Can result in adaptive (increases survival advantage) phenotype or maladaptive phenotype (these individuals are weeded out of the population) We see that non-coding regions are most-commonly effected by insertion and deletions. Our protein coding genes have a relatively baseline level of cnvs that occur.
