BIO200H5 Lecture Notes - Lecture 14: Ring Strain, Glucuronidation, Dd-Transpeptidase
Document Summary
Several biological and environmental factors affect drug metabolism and the. Factors affecting drug metabolism; excretion of drugs from the body. Prodrugs; masking drug metabolism or severe first-pass effect target tissue well (ex. / crossing the bbb) pharmacologically active drug. Some drugs can"t be administered as active components due to rapid renal clearance. Depending on location of drug action: some parent compounds can"t permeate to. Enhance drug-like pk properties (adme) of administered drugs. Promoiety = should be safe after metabolism, and rapidly cleared from body. Drug = should show enhanced bioavailability, solubility, and/or delivery to site of. Chemotherapeutics - create a very difficult environment for people going through it - 1. improve oral absorption and aqueous solubility (necessary for effective drug permeation) 2. enhance lipophilicity and active transport (ex. / recognition by specific transporters/carrier proteins) Things are able to cross the blood-brain barrier. Ex of prodrug:// levodopa l-dopa prodrug for dopamine. Enhances active transport to chance of action.