BIO200H5 Lecture Notes - Lecture 16: Twin Study, Prodrug, Myopathy
Document Summary
In division process, people who contain disease factor they will have more than the ones that got from inheritance". Cnvs in some genes= evolved as adaptation to environment. Produced by saliva , helps with further starch digestion. 2-17 repeat cnv for alpha-amylase 1(amy1) gene. Adaptative cnv: increase in populations with high starch diets. Adaptation: low copy number it could predispose for obesity. because not making so much amylase ( less transcription of genes) Those who have a copy number above 10 : normal and below 10 : high obesity rate and also develop early don"t control their lifestyles. Good pharmaceutical programs : we can pass on these genes in populations who. Polymorphism in certain transporters can alter by bioavailability, These transport helps drugs transport in body and regulate their metabolism in the body. Snps can either increase the affinity of drug molecules or decrease the affinity of drug molecules: also change substrate affinity to drug molecules.
