BIO200H5 Lecture Notes - Lecture 18: Sterol, Aids, Amphotericin B
Document Summary
Several biotic and abiotic factors can influence drug response, beyond what we have studied thus far (ex. / age, sex, weight, distribution, endogenous ligand concentration, etc. ) Ingested pollutants can interfere with drug action. Pollutants and drug response; drug therapies over time. Ex. / acquired resistance to sodium stibogluconate, a treatment. 300 million people at risk of infection worldwide; 1-2 million newly. Can survive for decades in infected, asymptomatic people. Late 1970"s: epidemic re-surged, due to resistance. Timeline of resistance onset = coincided with installment in india towards antimonials of shallow tubewells across asia. Affected 7. 2 million people across bihar, india. 2002 ) ex. / gsh conjugation) to clear arsenic (iii) from body. Co-existence of arsenic contamination and antimonial resistance. Other countries where leishmaniasis is endemic (sudan, brazil): no arsenic mechanisms contamination & . Drugs can enhance or interfere with each others actions. Drugs usually act on different effector systems/receptors. Hiv = human immunodeficiency virus; infection results in acquired.
