BIO202H5 Lecture Notes - Lecture 47: Autocrine Signalling, Cell Signaling, Sarcolemma

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1 Oct 2018
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Signal takes longer to be achieved but is long lasting. One example of a neurotransmitter we previously talked about is acetylcholine (ach). Explain one role of this neurotransmitter in the body by using the following terms: action potential, calcium, ach-receptor, sarcoplasmic reticulum, and sarcolemma. Acetylcholine (ach) is a neurotransmitter that plays an important role in how muscles receive signals from neurons. An action potential travelling down an axon and eventually reaching the synaptic terminals of a neuron triggers voltage-gated calcium ion channels to open and calcium ions rush into the synaptic terminal space. Calcium ions trigger migration and exocytosis of synaptic vesicles that are filled with ach. Ach is then release into synaptic cleft and attaches to the. Ach-receptor in the synaptic cleft/on the postsynaptic membrane (in this case a muscle cell) Ach and ach receptor association triggers influx of positive ions, such as sodium, into the postsynaptic cell.

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