BIO210Y5 Lecture Notes - Lecture 5: Skeletal Muscle, Epimysium, Endoplasmic Reticulum

<From the desk of Michael Brennan>

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Tue 9/19/2017 4:17 PM

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Here is the exam review for our next major lecture exam which will be on Monday. Notice that there are a few things missing, such as endochondral ossification. These will be added so just because it does not show up on this exam review doesn't mean you shouldn't study it. That being said, the details of each and every bone which I've gone over in lecture will be on the lab practical rather than the written lecture exam.

Anat 1, Exam 2. Spr 2016 LASC Name:____________________________________________________

1) A synarthrosis: a) is filled with synovial fluid. b) allow for a wide range of movement. c) includes the squamosal suture. d) is exemplified by the shoulder. e) all of the above.

2) Bursae: a) are located in the right atrium. b) are like elastomeric shock absorbers. c) are found in skeletal muscle fibers. d) form the sarcoplasmic reticulum. e) none of the above.

3) Irregular bones: a) can act like cams. b) can provide sites for muscle attachment. c) can protect soft-tissue organs. d) can act as levers. e) all of the above.

4) Condyles: a) are smooth articular surfaces. b) allow blood vessels to enter the bones. c) occur beneath the nail body after an injury. d) are produced by infected sebaceous glands. e) none of the above.

5) A head: a) is where you will find hyaline cartilage. b) is a smooth articular surface. c) is where a bone meshes with another bone. d) all of the above. e) none of the above.

6) Which of the following is the proper sequence of things following a bone fracture: a) hematoma, fibrous callus, bony callus, remodeling. b) hematoma, bony callus, fibrous callus, remodeling. c) hematoma, remodeling, fibrous callus, bony callus. d) hematoma, remodeling, bony callus, fibrous callus. e) fibrous callus, bony callus, remodeling, hematoma.

7) A diaphysis: a) contains yellow bone marrow. b) contain a lot of spongy bone tissue. c) occurs at the ends of long bones. d) all of the above. e) none of the above.

8) Short bones: a) protect underlying soft tissue organs. b) include the ribs. c) include the cranial bones of the skull. d) transfer mechanical forces. e) all of the above.

9) Fibrous joints: a) contain cruciate ligaments. b) include the pubic symphysis. c) are typically found in third class levering systems. d) include the lambdoid suture. e) all of the above.

10) Which of the following doesn’t belong? a) tibiofibular joint. b) dentino-alveolar joint.
c) intervertebral disc. d) radioulnar articulation. e) cartilage.

11) Which of the following doesn’t belong? a) atlanto-occipital joint. b) humero-ulnar joint. c) frontal suture d) acromio-humeral joint. e) tibiotarsal joint.

12) Hyaluronic acid: a) forms the extracellular matrix. b) is found in fibrous joints. c) keeps cartilage soft and pliable. d) is found in synostoses. e) none of the above.

13) First class levers: a) include the tibio-tarsal joint. b) have the effort between the fulcrum and the load. c) are like a teeter-totter. d) all of the above. e) none of the above.

14) Synchondroses: a) are typically synovial joints. b) allow for very limited movement. c) include sutures and gomphoses. d) are encased in synovial capsules. e) none of the above.

15) Parallel muscles: a) have long excursions. b) include the abdominal muscles. c) have excellent endurance. d) have low strength. e) all of the above.

16) Sphincteral muscles: a) enclose openings or passageways. b) are used when you talk.
c) surround the eyes. d) include the orbicularis oculi. e) all of the above.

17) Pennate muscle architecture: a) is typified by the pectoralis major. b) have high endurance.
c) generates high strength. d) has a longer excursion. e) all of the above

18) Endomysium: a) consists of dense fibrous connective tissue. b) surrounds each fasciculus.
c) surrounds bundles of muscle cells. d) all of the above. e) none of the above.

19) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

20) A tuberosity: a) is a hollow opening. b) is a shallow smooth articular surface. c) is a raised area that adjoins a condyle. d) is a larger outwardly curved articular surface. e) is a raised, rough-textured area.

21) Which of these doesn’t belong? a) tuberosity b) trochanter c) condyle d) tubercle e) lunula

22) Epimysium: a) wraps around the entire muscle. b) is made of dense fibrous connective tissue. c) is continuous with tendons. d) all of the above. e) none of the above.

23) Which of the following is more likely to be an insertion rather than an origin? a) ulna.
b) cervical vertebra. c) thoracic vertebra. d) rib. e) Ischium.

24) Which of the following is more likely to be an origin rather than an insertion? a) clavicle.
b) tibia. c) radius. d) ulna. e) metatarsal.

25) Myofibrils: a) are composed of many muscle fibers. b) are composed of many muscle cells.
c) are composed of many sarcomeres. d) form the endomysium. e) all of the above.

26) Myosin: a) helps keep muscle cells from overstretching. b) is a protein. c) joins thin filaments together. d) forms part of the z-disc. e) all of the above.

27) Sarcolemma: a) surrounds the entire muscle organ. b) surrounds the endomysium.
c) is the cell membrane of a muscle fiber. d) surrounds the epimysium. e) none of the above.

28) Thin filaments: a) are made of titin. b) are pulled on by the thick filaments during contraction.
c) create the molecular “power-stroke”. d) all of the above. e) none of the above.

29) A second class lever: a) is like a wheel barrow. b) is like a teeter-totter. c) describes the humeroulnar joint. d) describes the atlanto-occipital joint. e) none of the above.

30) A sarcomere: a) is the basic unit of muscle function. b) is made mostly of proteins. c) shortens during a contraction. d) delivers an “all or none” response. e) all of the above.

31) Fast glycolytic fibers: a) have excellent endurance. b) deliver lots of power.
c) are more reddish in color than oxidative fibers. d) none of the above. e) all of the above.

32) Which of the following doesn’t belong? a) Vastus lateralus. b) Vastus intermedius. c) Vastus medialis. d) Rectus Femoris. e) Gluteus minimus.

33) Which of the following doesn’t belong? a) Teres major. b) Teres minor. c) subscapularis.
d) infraspinatus. e) supraspinatus.

34) Tendon sheaths: a) are filled with synovial fluid. b) can be likened to brake and shifter cable sheathing on a bike. c) are found around the carpal bones. d) really make life unpleasant if they get inflamed. e) all of the above.

35) Epithelial tissues: a) function in movement. b) conduct electrical impulses. c) form a structure for attachment of other organs. d) form barriers and walls. e) all of the above.

36) Elastic connective tissue: a) is found in bone. b) lines the inside of the trachea. c)Is found in small blood vessels like capillaries. d) is found in large arteries. e) all of the above.

37) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

38) Dense regular connective tissue: a) is poorly vascularized. b) heals slowly if at all. c) forms tendons and ligaments. d) can look a lot like smooth muscle under the microscope. e) all of the above.

39) Transitional epithelium: a) lines the urinary bladder. b) lines the blood vessels. c) contains cilia. d) joins the epidermis to the dermis. e) none of the above.

40) Skeletal muscle: a) responds to conscious thought. b) is found in the heart. c) is found in the walls of blood vessels and the GI tract. d) is composed of very small cells. e) all of the above.

For the following matching questions, each choice is used only once.

41) Fibroblast a) maintains bone tissue
42) Mast Cell b) secretes mucus
43) Chondrocyte c) responsible for inflammation response
44) Osteocyte d) makes collagen fibers
45) Goblet Cell e) maintains cartilage

For the following true-false questions, mark “A” for true and “B” for false.

46) Simple cuboidal epithelium is lines the trachea and Fallopian tubes/oviducts.
47) Elastic cartilage joins the ribs to the sternum.
48) An insertion is the more movable point of muscle attachment.
49) Tendons connect muscle to muscle or bone to bone.
50) Ligaments connect muscle to bone.
51) Transverse tubules allow nutrients to be dispersed throughout very large muscle cells.
52) Muscle twitch occurs when only a few muscle cells in the entire muscle are fully contracted.
53) Slow oxidative fibers have poor strength but excellent endurance.
54) Muscles can lengthen under their own power as well as contract.
55) Pott’s fracture is typical of skateboarders.
56) An incomplete fracture is a complete break through the entire bone.
57) Tetanus is the recruitment of additional fibers during muscle contraction.
58) Menisci are like elastomeric shock absorbers.
59) Diarthrotic joints allow for little to no movement.
60) A belly is the contractile portion of a muscle.
61) Synergistic muscles work with each other.
62) Muscle tissue, like your lab instructor’s evil twin before his morning coffee, is irritable.

Reflex Lab Procedures for Reflex Lab In this lab we will test muscle stretch reflexes and cutaneous reflexes. A partner is needed to be the subject for this lab. Purpose: To test and observe normal muscle stretch and cutaneous reflexes. Equipment: Reflex hammer, Background: In the most narrow sense, a reflex is an involuntary, unpremeditated response by the body to an external stimulus. Reflexes allow reaction to a stimulus more quickly than would be possible if conscious thought were involved. A reflex can be described as a stimulus-response cycle. Most reflexes involve the brainstem or the spinal cord and do not require interaction from higher brain centers. The muscle stretch reflexes are the simplest reflexes. They involve the sensory neuron synapsing directly upon the motor neuron. They are sometimes called monosynaptic reflexes. They are also called spinal reflexes because the reflexive action does not require input from the brain. The other reflexes we will be testing in this lab are the cutaneous reflexes. They are also called superficial reflexes because the receptors are in the superficial areas of the body. They are more complex and require the message to go up the spinal cord to the brain and then back down to elicit the response. These can be used to test for CNS injury. There are five components to a reflex; these components together are called the reflex arc. The components are as follows: sensory receptor – receives the stimulus and generates an impulse (is usually a nerve ending) afferent pathway – a neuron that carries the impulse from the receptor to a central integrating center integrating center –this is where the afferent component connects to the efferent component- this is in the CNS. One or more synapses must occur here. Interneurons are not involved in stretch reflexes but are always found in all other types of reflexes. efferent pathway - a neuron that carries the impulse from the integrating center to an effector. effector -receives the impulse and responds. The effector may by skeletal muscle, smooth muscle, or glands.

Part I. Stretch reflexes.

First do muscle stretch reflexes which are also called deep tendon reflexes.

It is important the subject relax the muscle being tested. Tell the subject to let the muscle go limp.

Rate each response according to the following scale:

+4 very brisk, hyperactive, large movement at joint.

+3 brisker than average, medium movement at joint

+2 average, small movement at joint

+1 somewhat diminished, very small or no movement at joint

0 no response

A. Patellar (also called the knee jerk reflex) – activation of femoral nerve. The receptor is located in the quadriceps muscle, the effector is the quadriceps muscle. The nerve ending is responding to the stretch of the muscle caused by striking the tendon.

1. A subject is allowed to sit comfortably on a table with knees dangling over the edge.

2. Using a reflex hammer (or substitute as described above) strike the patellar tendon just below the kneecap.

3. Observe the action caused by the reflex.

4. Record your results using the graded scale above.

B. Biceps Reflex – activation of the musculocutaneous nerve

1. Rest subject’s left forearm along your left forearm.

2. Subject’s hand should rest in or near the bend of your elbow.

3. Press your left thumb on the subject’s biceps tendon, apply a little pressure.

4. Strike your thumb with the reflex hammer, this will transfer the pressure to the biceps tendon.

5. Watch carefully for twitching of the biceps muscle. Usually, the forearm will not move.

6. Record your results using the graded scale above.

C. Triceps reflex – activation of the radial nerve.

This is a difficult reflex to observe, but give it a try.

1. The subject should have the arm relaxed and elbow bent.

2. Support the entire weight of the arm with your left hand.

3. Strike the triceps tendons, just above the elbow.

4. Watch carefully for twitching of the biceps muscle.

5. Record your results using the graded scale above.

Both B and C show up best on someone who doesn’t have a lot of subcutaneous fat and who has good muscle definition.

D. Achilles reflex (also called ankle-jerk reflex) – activation of the poplitealnerve. The principle is similar to the knee-jerk reflex. Here the stretch receptors are located in the gastrocnemius muscle.

1. Have the subject take her/his shoes and socks off, exposing the Achilles tendon on the back of the ankle.

2. Strike the Achilles with the reflex hammer (or substitute) and observe the extension of the foot downward.

3. Record the results using the graded scale above.

Part II. Cutaneous reflexes

A. Plantar reflex

This reflex differs from the four muscle stretch reflexes. In this reflex, receptors are stimulated in the sole of the foot (cutaneous receptors). The reflex pathway travels up the leg to the integrating center. While in the integrating center, the reflex travels up the spinal cord through the pyramidal tracts, which are nerve pathways between the spinal cord and brain.

1. The subject needs to lie on his or her back, with shoes and socks off.

2. Using the end of the handle of the reflex hammer, trace a path along the lateral side from heel to the little toe to the big toe.

3. Observe for the flexion (toe curling) which is recorded as a normal plantar reflex.

4. If the toes curl, this is called a Negative Babinski response and is normal. If the toes flare, then an abnormal response is recorded and is called a Positive Babinski response and indicates CNS damage.

5. Record the results.

B. Ciliospinal reflex – This reflexive pathway is from the skin to the thoracic spinal cord, through the sympathetic trunk, then to the dilator pupillae muscle of the eye. This is another test of the CNS.

1. Pinch the back of the subject’s neck,

2. Watch pupils for a response.

3. A normal response is dilation of the pupil.

4. Record your results.

Hello everyone, i'm working on thesepractices multiple choices for my finals. If you know any of theseanswer, please help. i appreciate your time and your help. Thankyou!!!

1. ___ Which of thefollowing statements about the cytoskeleton is false?

(a) The cytoskeletonis made up of three types of protein filament.

(b) The bacterialcytoskeleton is important for cell division and DNAsegregation.

(c) Protein monomersthat are held together with covalent bonds form cytoskeletalfilaments.

(d) The cytoskeleton of acell can change in response to the environment.

2. ___ Which of thestatements below about intermediate filaments is false?

(a) They can stayintact in cells treated with concentrated salt solutions.

(b) They can befound in the cytoplasm and the nucleus.

(c) They can beanchored to the plasma membrane at cell-cell junction.

(d) Each filament is about10 ?m in diameter.

3. ___ Keratins,neurofilaments, and vimentins are all categories of intermediatefilaments. Which of the following properties below is nottrue of these types of intermediate filaments?

(a) They strengthencells against mechanical stress.

(b) Dimers associateby noncovalent bonding to form a tetramer.

(c) They are foundin the cytoplasm.

(d) Phosphorylation causesdisassembly during every mitotic cycle.

4. ___ Which of thefollowing statements about microtubules is true?

(a) Motor proteinsmove in a directional fashion along microtubules by using theinherent structural polarity of a protofilament.

(b) The centromerenucleates the microtubules of the mitotic spindle.

(c) Becausemicrotubules are subject to dynamic instability, they are used onlyfor transient structures in a cell.

(d) ATP hydrolysis by atubulin heterodimer is important for controlling the growth of amicrotubule.

5. ___ Thehydrolysis of GTP to GDP carried out by tubulin molecules________________.

(a) provides theenergy needed for tubulin to polymerize

(b) occurs becausethe pool of free GDP has run out

(c) tips the balancein favor of microtubule assembly

(d) allows the behavior ofmicrotubules called dynamic instability

6. ___ The microtubulesin a cell form a structural framework that can have all thefollowing functions except which of the following?

(a) holding internalorganelles such as the Golgi apparatus in particular positions inthe cell

(b) creating longthin cytoplasmic extensions that protrude from one side of thecell

(c) strengtheningthe plasma membrane

(d) moving materials fromone place to another inside a cell

7. ___ Which of thefollowing statements about organellar movement in the cell isfalse?

(a) Organellesundergo saltatory movement in the cell.

(b) Only themicrotubule cytoskeleton is involved in organellar movement.

(c) Motor proteinsinvolved in organellar movement use ATP hydrolysis for energy.

(d) Organelles areattached to the tail domain of motor proteins.

8. ___ Which of thefollowing statements is correct?

Kinesins and dyneins____________________.

(a) have tails thatbind to the filaments

(b) move along bothmicrotubules and actin filaments

(c) often move inopposite directions to each other

(d) derive their energyfrom GTP hydrolysis

9. ___ Cell movementinvolves the coordination of many events in the cell. Which of thefollowing phenomena are not required for cell motility?

(a) Myosin-mediatedcontraction at the rear of the moving cell.

(b) Integrinassociation with the extracellular environment.

(c) Nucleation ofnew actin filaments.

(d) Release ofCa²⁺ from the sarcoplasmic reticulum.

10. ___Which of the followingstructures shorten during muscle contraction?

(a) myosinfilaments

(b) flagella

(c) sarcomeres

(d) actin filaments

7. ___ Referring to Figure Q16-29,which of the following statements below is false?

(a) A constitutivelyactive mutant form of PKA in skeletal muscle cells would lead to adecrease in the amount of unphosphorylated phosphorylasekinase.

(b) A constitutivelyactive mutant form of PKA in skeletal muscle cells would notincrease the affinity of adrenaline for the adrenergicreceptor.

(c) A constitutivelyactive mutant form of PKA in skeletal muscle cells would lead to anexcess in the amount of glucose available.

(d) A constitutivelyactive mutant form of PKA in skeletal muscle cells would lead to anexcess in the amount of glycogen available.

8. ___ Match the targetof the G protein with the appropriate signaling outcome.

adenylyl cyclase________ A. cleavageof inositol phospholipids

ion channels_________ B.increase in cAMP levels

phospholipase C_________ C. changes in membranepotential