Class Notes (810,913)
Canada (494,374)
Biology (2,100)
BIO200H5 (110)
Lecture 8

BIO200 Lecture 8

11 Pages
Unlock Document

University of Toronto Mississauga
Mc Intyre Burnham

Lecture 8 October-08-13 4:09 PM Drug levels drop all over body We need to be absorbing molecules all the time so we also need to be eliminating Removal from liver and kidney Ex. Chlorolose from cats The body is capable of eliminating anything Lectures Page 1 You can estimate half life here (real world graph) = TBC in kidney or liver (or a combination) Overdose of SA will make a pseudo-zero order We can never get Co because equilibrium takes time When finding k, use slope from this graph (semi-log plot) It is reverse image of when we're dosing (adding molecule goes up then levels off) When concentration is high in blood, kidney and liver work efficiently - routes of elimination Elimination is first order. Proportion of elimination increases, but the absolute # molecules being eliminated decreases - Applied to drugs (Calculating how much drug is eliminated) - Elimination rate (proportion/ percent of drug eliminated per unit time) - Body fluid is clear of drug (Calculating how many leaders are cleared) TBC: total body clearance - Apparent volume of distribution - sum of all clearance = Cl (hepatic) + Cl (renal) Lectures Page 2 Shortest half life are for drugs broken down in blood because blood has soluble enzymes Ex. ASA is half gone within 15 min. Lungs - major route of elimination for gaseous drugs Ex. anaesthesia (this is easy to reverse) Saliva - a sample of body water which is a good way to tell how much drug is in the body (since drug is equilibrated there) Enzyme barriers in BBB Memorize, they don't make sense >.< Slope - refer to semi-log presentation above Half-life can be estimated by the real world graph, it is more accurate if gotten from the semi-log curve k = proportion of drugs per liter It is related/ proportional but they are not the same (ex. long half-life, long therapeutic effect) Lectures Page 3 This is in the chart Slope = y/x = always negative Lectures Page 4 (per hour) Cl - a fiction k - based on fiction Lectures Page 5 Kidneys are able to eliminate low Po/w drugs but cannot get rid of high P o/w drugs High Po/w drugs will
More Less

Related notes for BIO200H5

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.