BIO200H5 Lecture Notes - Lecture 19: Chloramphenicol, Digoxin, Skeletal Muscle
Document Summary
We don t have much specialization in old people. Babies and adults have differences in drug elimination , they are often overdosed because they eliminate slower. Baby stomach is not as acidic as adult stomach, it"s gastric ph is closer to blood ph. More than half is broken in the stomach (but wont happen in babies) Baby total body water is large, if you give low partition coefficient drug, you are under-dosing the baby. Liver is large (twice the baby"s body size) Skeletal muscle quite small - this will matter in taking in drugs that enter i. m (ex. Hb is broken down, cannot be metabolize at first so bilirubin is produced (this is quite toxic to the brain) The drug is very toxic in the brain. May have motor problems, sensory problems, cannot die tho. Liver and kidney are malfunctioned so be careful in dosing. Liver and kidney is large and functional but you still have high total body water.
