BIO374H5 Lecture Notes - Lecture 2: Gene Knockout, Agricultural Biotechnology, Genetically Modified Organism
Document Summary
Transgenic animals overexpressed some genes to see diseases we study: animals as important models in basic research. Gene knockout experiments allele casket that is inserted into an animal and the gene is carried into further generations. Design and testing of drugs and genetic therapies: animal cloning. Disrupt a gene in the animal and then look at what functions are affected in the animals as a result of the loss of the gene. This allows researchers to determine the role and function of the gene. Since humans are similar to rats and mice, gene knockout studies in rats and mice can lead to better understanding of gene in humans. Example of a gene that can be knockout in mice: knockout gene coding for insulin study diabetes: forensic biotechnology, dna fingerprinting. Inclusion or exclusion of a person from suspicion. Yes, the blood from the defendants" clothes matches with the victim"s blood so defendant is most likely is related to the crime: bioremediation.
