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Lecture 30

BIO380H5 Lecture 30: Lecture 30- The Respiratory System -Pgs 359-367-

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Department
Biology
Course
BIO380H5
Professor
Nagham Abdalahad
Semester
Fall

Description
The future respiratory gut is located in the ventral foregut Specification by WNT and FGF signals from the adjacent mesoderm Late 4th week- lung buds begin to protrude from the posterior part of the respiratory endoderm Creation of a septum separating the newly formed trachea from the esophagus from the mesodermal ridges growing inward which are present dorsal to the lung buds Interactions with surrounding mesoderm = trachea + lung buds (respiratory diverticulum) elongates and begins a set of 23 bifurcations (division into two) Stages in Lung Development Embryonic Stage (Weeks 4-7) Initial formation of the respiratory diverticulum up to the formation of all major branchopulmonary segments Developing lungs grow and begin to fill the bilateral pleural cavities Pseudoglandular Stage (Weeks 8-16) Formation and growth of the duct systems within the bronchopulmonary segments before their terminal portions form respiratory components Pulmonary arterial system begins to
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