CHM362H5 Lecture Notes - Lecture 32: Cell Membrane, Homeostasis, Integral Membrane Protein
Document Summary
Steroid hormones: derived from cholesterol, regulate metabolism, salt and water balance, inflammatory responses, and sexual function. Amino acid derivatives: i. e. epinephrine, which regulates smooth muscle function, blood pressure, cardiac rate, etc, i. e. thyroid hormones, which stimulate metabolism. Peptide hormones: small proteins (i. e. growth hormone, insulin, regulate processes in all tissues, including release of other hormones, hormones bind with very high affinity to their receptors. Kd values of 10-12 to 10-6 m. Modular binding domain recognition: specific protein interaction domains recognize specific sequences. Sh2 & ptb domains bind xxpyxx: signalling proteins can have multiple protein interaction domains. Integral membrane proteins with an intracellular site for a gtp-binding protein. Have an intracellular domain that is either a tyrosine kinase or a guanylyl cyclase: oligomeric ion channels. Multisubunit structures that function as ligand-gated ion channels. Single-transmembrane-segment catalytic receptors: i. e. epidermal growth factor receptor (egfr, human egf is a small protein (53 residues you don"t need to know the number)
