FSC402H5 Lecture Notes - Fall 2018 Lecture 2 - Anticonvulsant, 72 Hours (TV series), Warfarin
Document Summary
How drugs exert their effects: definitions of drugs by their action, agonists (ag) bind & active receptors, mimics endogenous compounds, generally binds at site that endogenous ligands binds, then triggers signaling cascade (biological response) Major receptor families: ligand-gated ion channels (rapid- milliseconds, regulate flow of ions across cell membranes, dr: binding of 2 acetylcholine to nicotinic receptor results in na+ influx, generation of ap, response (effect)- contraction in skeletal muscle, gaba receptor. When bound to gaba receptor, results in influx of. Reduces neuronal excitability: binding of benzodiazepine drugs to gaba receptor enhances binding of. Increases amount of glucose available to muscle cells within seconds: mechanism. Interaction of ag with gpcr facilitates coupling of activated receptor (r*) with intracellular heterotrimeric g proteins: r*-g protein coupling promotes exchange of. Gdp for gtp on ga-subunit: ga-gtp then dissociates from gby & r, both subunits are free to modulate activity of, enzyme-linked receptors (minutes to hours) wide variety of intracellular effectors.
