PSY397H5 Lecture Notes - Lecture 3: Protein Kinase, Resting Potential, Exocytosis
Document Summary
The animation presents a synapse with a presynaptic terminal bouton, postsynaptic membrane, and the synaptic cleft in between, synaptic vesicles are docked to the presynaptic membrane. Shown on the postsynaptic membrane are a receptor, a g protein, the enzyme adenylyl cyclase, and a transmitter-dependant potassium channel. Within the postsynaptic membrane the enzyme protein kinase and an atp molecule are shown. The animation describes an inhibitory synapse, wherein the binding of the transmitter to the postsynaptic metabotropic receptor leads to the opening of potassium channels indirectly via a second messenger. The action potential reaches the end of the axon and depolarizes the presynaptic membrane. This process is represented by red dots spreading in the terminal bouton. This depolarization of the terminal bouton causes voltage dependant calcium channels to open. Calcium ions flow into the cell and diffuse to the presynaptic membrane, where the synaptic vesicles are docked. Calcium causes synaptic vesicles (in this case, vesicles filled with the neurotransmitter.
