PSY397H5 Lecture 3: Lecture 12- Alzheimer's Disease .pdf
Document Summary
Age-related memory decline is not inevitable: the bimodal nature of distribution. An analysis of the effect of aging on recognition memory. Affected trans-entorhinal region can be clinically silent; entorhinal cortex subtle loss of episodic memory. Area ca1 and difficulty executing complex entirety of hippocampus progressive tasks; anecdotal repetition; some spatial disorientation. Early-stage ad; loss of episodic memory, difficulty with spatial reasoning and recognition, difficulty with coherent speech and planning. Fully developed ad; pronounced decline in cognition, frank dementia, can include psychosis or depression, ultimately a complete inability to communicate or care for themselves. 695 aa splice variant prion promotor human app v717f. No learning phenotype, accelerated plaque disposition when combined with app v717f(66, Decreased neurogeneis, accelerate memory deficits when combined with app/ps mutations (114) Genetic risk factors and causes: overexpression of app (as in down"s. Syndrome: mutations of app, mutations of presenilins, apoe4, tau. Training g n i z e e r f t n e c r e p.
