BIOB34H3 Lecture Notes - Lecture 22: Neuromuscular Junction, Endoplasmic Reticulum, Skeletal Muscle

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27 Nov 2016
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Lecture 22 muscle convert chemical energy to mechanical energy in a macroscopic sense. Skeletal muscle cells/fibres are multinucleate cells that are bundled up in connective gut, uterus) are smooth. Muscle cell membranes (sarcolemmas) have invaginations (t-tubules) that help to conduct voltage changes sarcomere regions. The interaction between myosin and actin filaments is ultimately what allows muscles to. Cross-bridge cycling: how myosin pulls on actin: myosin fibres have heavy chains (connective bit of tail to head/cross- brdige/lightchain), and the head of the myosin protein can grab actin protein and pull it. The actin filament is a chain of proteins connected. The myosin has an actin binding site and an atp binding site, when atp binds to the sit the myosin protein no longer binds to the actin protein and enters in a lifted-up state. The potential energy stored causes the cocking of the myosin head and now it binds to the actin filament (adp and pi still bound to myosin head).

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