BCH210H1 Lecture Notes - Lecture 10: Ionic Bonding, Circular Dichroism, Zygosity
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BCH210H1 Full Course Notes
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Lecture 10 outline: application of chou-fasman rules, hemoglobin, glucagon (peptide hormone) If changed to aspartic acid, it would be a conservative mutation. Hemoglobin a vs. s: sickle cell anemia is a chronic hemolytic disease that is genetically transmitted, hemoglobin a (hba) is a reversible oxygen carrier with. Single amino alteration in hemoglobin causes sickle cell anemia. Hemoglobin s val - his : codon change: glu(gag), val (gtg) Pro - glu - glu - lys - Pro - val - glu - lys : n-terminal of beta-chain read from b1 to b8. Separated hbs and hba on a starch gel by taking clinical blood sample from both populations and separate the two forms to see if there"s a difference. Starch gel electrophoresis requires protein in made-up conformation to identify it (different from sds) starch is a poly-glucose polymer, can boil it and allow it to cool rapidly, and end up with a gel.