CSB325H1 Lecture Notes - Lecture 3: Basement Membrane, Endothelium, Pars Intermedia
29 Nov 2014
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Lecture 3: hypothalamus- pituitary axes hypothalamus: where most of our hormones will be found: where most of our secreting factors are. Ventricles of the brain the brain and nerve cord are hollow and consists of. 4 ventricles filled with cerebral spinal fluid. Csf comes from spine into the brain (1st, 2nd, 3rd, and 4th ventricles) Forebrain (ventricles i and ii) Humans have complex ventricle system, which are all connected and bent over backwards. There are no substances in csf that are not found in plasma. There is a barrier between the blood and csf (blood- brain barrier) instant death is there is no bbb. The four basic components: endothelial cells, basement membrane, adventitial layer, glial cells. Restricts large and water- soluble molecules. Passive diffusion: water, lipophilic (steroids, eicosanoids), drugs (barbiturates), alcohol. Transporters: glucose, neutral amino acids used for neurotransmitter synthesis. Saturable transporters (facilitative diffusion, active transport): met- enkephalin, il- 1, npy, mch, crf.
