HMB200H1 Lecture Notes - Lecture 7: Brain Stimulation Reward, Dopamine Receptor D2, Nucleus Accumbens
Document Summary
Also causes dopamine and behavioural activation in terms of parkinson"s disease and movement. Drug rewards such as cocaine, opioids, nicotine, and amphetamine. Stimulation of tectum: approach turns: intermediate layers, moderate stimuli, crossed tectospinal path, avoidance turns: deep layers, intense stimuli, uncrossed tecopontine path, defensive responses: pag, glutamate stimuli, descending paths. Approach, arousal and reward: tectospinal path produces turning & foveation of visual stimuli, cholinergic activation thalamus, basal forebrain, dopamine activation wide spread cortical arousal. Nigrostriatal dopamine system important for energizing dopamine activation system: loss leads to loss of energy, movement initiation, 90% loss in ventral striatal parkinson"s, loss of motor control. Dopamine neurons in disease (carlsson, seeman: parkinson"s disease loss of energy, initiative, affect. Brain-stimulation reward and drug self-administration: 1960s, mcgill olds and milner, rats will bar-press for rewarding stimulation, hypothalamic or tegmental stimulation of the midbrain lets the mice get excited/aroused and keeps them bar-pressing.
