HMB265H1 Lecture Notes - Lecture 14: Gene Product, Genetic Linkage, Chromosome

• School: UTSG
• Department: Human Biology
• Course: HMB265H1
• Professor: Maria Papaconstantinou

Document Summary

There are many false-positives as there are many coincidences. Not all correlations are true, as this involves full seq, and no experiments. Number of genes can have major effect on phenotype. Quant effect can be attributed to >= 2 important genes. Qtl typically have allelic variance that makes a small quantitative contribution. Want to identify where this are - mapping allows this. Qtl mapping was done first on crop plants, but now is broadly applied. Fundamental idea: one can identify qtl in genome using marker loci that are linked to qtl. Cross inbred, related individuals that differ at the traits of interest. Must be as similar to each other in all other respects. Example to be used: tomato - used very widely in various methods. Cross a giant tomato with a small tomato. Usually crosses are between indivs of the same species, but can be done with very related species with similar genomes.