PSL300H1 Lecture Notes - Lecture 4: Adenylyl Cyclase, Metabotropic Receptor, Muscarinic Acetylcholine Receptor
Document Summary
Binding of a transmitter causes a change in shape of the receptor protein. Metabotropic (initiates a metabolistic cascade to activate enzymes) Ligand binds and opens an ion channel. Binding of the transmitter to the postsynaptic membrane results in a change in postsynaptic membrane potential (post synaptic potential - psp) Ion channels either specific for cations for depolarizing (epsp) or for cl-,k+ for hyperpolarizing (ipsp) Examples of ligands for ionotropic receptors (transmitters that can act on ionotropic receptors) It is the receptor that determines the effect, not the transmitter. Binding of the ligand to the postsynaptic metabotropic receptor activates an enzymes that is usually g-protein coupled. Enzyme facilitation will result in increased production or destruction of 2nd messengers. 2nd messengers are either camp, cgmp or inp3. There are more steps in between (when the ligand binds to the receptor to when the effects take place thus, these effects take longer time) It binds to the metabolic receptor for noradrenaline (na)
