PSL300H1 Lecture Notes - Lecture 19: Cholecystokinin, Vagus Nerve, Fenfluramine
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Feedback v there is neuronal feedback: through the sympns activity feeding into the two groups of arcuate neurons v there are also other types of feedbacks, like that from the body. The hypothalamus infers body weight from leptin levels. Jackson transgenic mice labs has actually created two types of. Db/db mice that also gain weight because they have a problem with the leptin receptor. Leptin also excites arc-pomc and vmh, and inhibits dmh v leptin also works on pomc neurons and well as the vmh. Psl300 human physiology i v there is also a really strong drive that inhibits the dmh v both these feedbacks inhibit feeding behaviour. Brain v not from leptin, because it is too slow, you don"t lay on much new fat during a single meal. They also excite the vagus nerve, which excites vmh via the nucleus tractus solitarius, nts.
