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Lecture 7

BIOL 150A Lecture Notes - Lecture 7: Fibrin, Vasodilation, Leukopenia

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Midterm Lab Study Guide
Lab 1
oPlastic sharps container
oBiohazard bag/ autoclave bag
oBleach container
Identification of Leukocytes, erythrocytes, and thrombocytes
Formed Element Structure Function
Erythrocyte Biconcave
No nucleus
Spectrin protein
oAllows for decreased distance for diffusion
oProvides faster gas exchange
Transports O2 and CO2
250 million Hb molecules per RBC
o4 O2 molecules bind reversibly to Heme (iron) portion of each Hb
oCO2 binds reversibly to globin (protein) portion of Hb
Mature RBC ejects nucleus and mitochondria
oMore room for Hb, no O2 wasted by RBC
Network of spectrin protein on inner surface of RBC plasma membrane
oMaintains shape when travelling through capillaries
Neutrophil Multi-lobed
Most common
Phagocytic- contains digestive enzymes
Engulfs bacteria, fungi and damaged and dying cells
Release cytotoxic enzymes and chemicals
Contains anti-bacterial proteins
Lymphocyte Round nucleus
Little cytoplasm
Cells of lymphatic system
Most common in spleen and lymph modes
Provides defense against pathogens and toxins
Contains T-cells destroy infected cells/ tumor cells
Contains B-cells plasma cells produce antibodies- label and clump
bacteria and viruses
Monocyte Very large
Kidney bean
shaped nucleus
Turn into macrophages which are phagocytic
Occurs in tissues- engulfs pathogens or debris
Eosinophil Red granules
2-lobed nucleus
Stain red
Release digestive enzymes to destroy parasites
Increase in parasitic infections
Involved in allergic response, reduce inflammation release anti-
Phagocytic-engulf antibody labelled material
Release cytotoxic enzymes
Basophil Round
Nucleus not seen
Blue granules
Stain blue
Enter damaged tissues and release histamine and other chemicals that
promote inflammation
Secrete heparin anti-coagulant
Cause BV to dialate so WBC’s can arrive quickly and get into tissues
Also involved in allergic response
Thrombocytes Small cell
Membrane bound cell fragments
Contain enzymes and other substances important in clotting process
Coagulation plugs up damaged BV
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