BIOL 1111 Lecture Notes - Cdk Inhibitor, Cytokinesis, P53

• School: University of Windsor
• Department: Biological Sciences
• Course: BIOL 1111
• Professor: Habetler

Document Summary

Basic requirements: cell size doubles, chromosomes replicate, mtoc replicates spindle, chromosomes equally distribute, cell must divide (cytokinesis) G1 can decide to go quiescent (g0) or move on to s or die major decision-making phase: nutrients growth factors signals from other cells. G0 effectively have exited the cell cycle; no longer proliferating. S dna replication amt of dna in cell populations can be quantitated by facs. G2 prepares for mitosis; tetraploid state monitoring step cell enlargement. Mt"s grab chromosomes (motors at kinetochore) kinetochore capturing is monitored as a checkpoint cytokinesis waits for full separation. **embryonic cell cycle: s and m phases only** Anaphase a: separate chromosomes (dynein (-) motors walk along mt"s) Anaphase b: centrosomes separate (mt"s slide against each other) Complexes: each composed of different cyclin and different cdk combination. G1 / s cdk: promotes s phase from g1. M cdk targets have effect of chromo cond. (histone and condensin phos)