PSYC 2560 Lecture Notes - Lecture 8: Drug Tolerance, Alcohol Withdrawal Syndrome, Cannabinoid
1 Apr 2016
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Document Summary
Different routes of drug administration affect how quickly it affects the central nervous system. The quicker a drug passes through the blood-brain barrier, the greater the high. Some drugs are metabolized by the liver, blood binding to protein in alcohol. Prolonged administration of various drugs can result in. Cross tolerance: some drugs are similar in structure and the receptors they react with (amphetamines and cocaine) One can develop tolerance or sensitivity to different drug side effects. Metabolic tolerance is a limiting of the amount of drug getting to its target. Functional tolerance is a change in response to the drug. The number of receptors may shrink as tolerance builds. Drug affinity: how well a drug can fit to a receptor. Affinity may decrease, so drug can no longer bind as well. Withdrawal effects are generally the opposite of drug effects: the brain is rebounding. Withdrawal symptoms, by definition are a physical dependence.
