Biochemistry 2280A Lecture Notes - Lecture 3: Carboxylic Acid, Oligopeptide, Protein Folding

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Net charge of amino acids: to find overall net charge, need to add up net charge of all ionisable groups at a given ph, example: asp at ph 7. All proteins are polypeptides but not all polypeptides are proteins. Primary structure (aa sequence): (amino acid sequence: dictates secondary, tertiary and quaternary structures, possess all information required. Hydrogen bonds form when a hydrogen atom is sandwiched between two electron-attracting atoms (usually o or n). Strongest when the three atoms are in a straight line. 1/20th of the strength of a covalent bond. 2o structure: the: spiral structure bone atoms, about 3. 6 amino acids, h bonds are key to. Example of a protein containing alpha helical structure: haemoglobin. Ompg (beta barrel)- pore forming bacterial membrane protein: allows things to pass through membrane that usually doesn"t. This channel can open and close using a signal. Concerns the 3-d arrangement of a single polypeptide chain.

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