Biochemistry 2280A Lecture Notes - Lecture 12: Flavin Adenine Dinucleotide, Lipid Bilayer, Cytosol
23 Dec 2017
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Note that fa metabolism is used (released from liver) under conditions of low glucose. Fa from stored as triacyglycerol can be degraded into acetyl-coa. When energy is needed (and there aren"t enough carbohydrates), fat cells adipocytes degrade triacylglycerol into glycerol + 3 fa"s. Fat metabolism can not be used for the brain. Fa synthesis (takes acetyl coa and makes fa) Ketongenesis (takes acetyl coa and converts it to ketone) Fa must rst be activated with co-a to be allowed into the matrix before entering - oxidation to produce acetyl coa. Attachment of coa to acyl-coa requires 1atp. An atp is broken to amp and ppi in order to yield enough energy to form thioester bond b/w acyl and coa. Acyl coa is allowed into the mitochondrial matrix (we want the rxn to happen in the matrix so that the product can be used immediately for ca cycle) Acyl-coa enters a rxn cycle ( -oxidation) that is made of 4 steps.
