Biochemistry 2280A Lecture Notes - Lecture 11: Pyruvic Acid, Coenzyme Q10, Phosphorylation

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carminewalrus808

22 Jan 2018

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Coenzyme: organic cofactor, often a reaction substrate. Prosthetic group: tightly bound cofactor (usually metal ion or coenzyme) Oxidation of nadh and fadh2 to pump h+ to harvest energy for atp synthesis: occurs in inner mitochondrial membrane (containing matrix) Electron carriers: (lowest electron affinity to highest: flavins: isoalloxazine ring (fadh2) **3 rings + chain*, gets 2 electrons (cofactor that is usually bound to enzyme permanently If there is more than 1 copper in the centre, each can accept an electron (unlike iron centres where regardless of how many iron molecules only 1 electron is accepted) Protein complexes: 4 protein complexes, each increasing in electronegativity (so they can attract the electrons, net etc reaction for: Matrix nadh = 1 nadh: 10h+ pumped into ims. Cystolic nadh = 1 nadh: 6h+ pumped into ims. Fadh2 = 1 fadh2: 6h+ pumped into ims: nadh dehydrogenase: accepts electrons from nadh **proton pump** 1 matrix nadh = 2. 5 atp (drives movement of 4h+)

Related Questions

1. During the TCA cycle, four reactions occur in which a pair of electrons are transferred from a substrate to an electron accepting coenzyme. These reactions are catalyzed by?

2.During the TCA cycle, four reactions occur in which a pair of electrons are transferred from a substrate to an electron accepting coenzyme. These reactions are catalyzed by?

3.Potent respiratory poison, including carbon monoxide, azide and cyanide have their toxic effect by binding to the heme a3 site of _____.

4.The first step in the TCA cycle is the condensation of the two-carbon acetyl group with a four-carbon _____ to form a six-carbon citrate molecule?

5.The inner mitochondrial membrane is virtually devoid of ____, and and rich in ____, which are characteristics of bacterial plasma membranes.

6.Iron sulfur centers are joined to the protein by linkage to a sulfur atom of a/n ___.

7.Decarboxylation of pyruvate and transfer of the acetyl group to CoA , along with the reduction of NAD₊ is catalyzed by ___.

8.When FADH₂ is the electron donor, electrons are passed directly to ____ in the respiratory chain

9.With the exception of ____, all of the redox centers within the respiratory chain that accept and donate electrons are prosthetic groups.

10.It iis evident fromt eh net equation fo the TCA cycle that the primary products of the pathway are the reduced coenzymes _____.

11. Complex III catalyzes the transfer of electrons from ___ to ___.

12. The passage of a pair of electrons from NADH to ubiquinone in the respiratory chain is accompanied by movement of roughly four protons from (the) ___ to (the) ___.

13. When NADH is the electron donor, electrons pass the respiratory chain by means of ____.

14. The matrix of the mitochondrion has a gel-like consistency owing to the presence of a high conentration of _____.

These are questions I missed on a quiz the instructor does not post what the answers should be and has not responded to my emails please help.

Thanks,

Amber

Biochemistry 2280A Lecture Notes - Lecture 11: Pyruvic Acid, Coenzyme Q10, Phosphorylation

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