Biochemistry 2280A Lecture Notes - Lecture 24: Nuclear Pore, Nuclear Membrane, Cell Membrane
11 May 2020
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Document Summary
In multicellular organism, a dynamic structure that breaks down every time a cell needs to divide. Discovered 1719 by leeuwenhoek first organelle discovered: nuclear envelope double unit membrane structure, chromatin dna wrapped up in proteins, lighter is euchromatin actively transcribed genes. Function: organises, protects and regulates the genome, provide structural integrity, chromosomes occupy specific territories within the nucleus and is inherited by offspring, separates transcription and translation. Position position may change depending on the function the cell is carry out, cells that are proliferating must undergo the cell cycle and depending on the phase determines the nuclear position. Nuclear envelope : arises from the er, and the outer membrane is continuous with the endoplasmic reticulum, sorted into two distinct membrane domains, the membranes enclose a flattened sac called the perinuclear space. Function: tethers chromatin especially silenced chromatin, provides mechanical rigidity for the nucleus, mechanical linkage to the cytoskeleton enabling nuclear repositioning, e. g. during development.
