Biochemistry 2280A Lecture Notes - Lecture 31: Ultimate Tensile Strength, Basal Lamina, Triple Helix
11 May 2020
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Document Summary
A meshwork of proteins and hydrated macromolecules regulates migration, tissue integrity and cell shape, proliferation and differentiation. Specialised ecm not/ couldn"t be done by cells: bone calcified, hair fibrous and loose, tendons tensile strength, skin - elastic, cornea transparent. Can also occur in vascular form leading to arterial rupture at the heart and vessels are unable to survive. Sugars cushioning and space filling: known as the ground substance" most of the ecm is produced here, gag"s, disaccharide chains 70-200 units long, highly charges molecules allow water to be held within (hydrophilic properties). Proteoglycans sugars linked to proteins: serine (has a hydroxyl group, linking tetrasaccharide, 95% sugar around 80 saccharides anchored to a protein, glycoprotein around 60% sugar, 15 saccharides (shorter). Hyaluronic acid non sulphated, secreted across plasma membrane. Interact/ bound to the surface of the cell but on thee outside: epithelium"s interaction with the basal lamina determines polarity.
