Biology 2382B Lecture Notes - Lecture 11: Hydrolysis, Dna Replication, Retrovirus
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Kinases ( rtks ) extracellular ( ligand . binding) domain ligands include growth factors and insulin ) Single transmembrane a- helix cytoplasmic domain with intrinsic tyrosine. Kinase activity which is stimulated by ligand binding due to receptor dimerization ( adapter proteins are required ) Ras acts as a g- tpase switch protein to signal further downstream. Aberrant signaling is at the root of many human cancers. Rtks dimerization allows for trans auto phosphorylation of cytoplasmic domains phosphotyrosines serve as docking sites for downstream signal transduction proteins. Adapter proteins proteins contain unique domains adapter that recognize specific sequences. 1911 , rous injected a cell free extract from a chicken tumour sarcoma into healthy chickens and they all developed tumours the transmissible agent was determined to be. Varmus one of the genes within the virus encodes a tyrosine kinase. Highly conserved and found in humans the normal version of it is cellular. Src ) the viral version of it is viral.