Biology 2581B Lecture Notes - Lecture 10: Haemophilia B, Haemophilia A, Genomic Library
11 Feb 2017
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Finding a gene sequence based on its phenotype. Can be done with and without mapping information: without: need other information. Hemophilia a: cosegregates with colorblindness if have hemophilia a = also colour bind: locations are close together on the genome because they were inherited together. Hemophilia b: being hemophilic and colour-blind don"t appear in the same people. Studies made it clear that a and b (have a similar phenotype) are caused by two different genes: can inherit independently, one of them is close to the gene that is causing colorblindness. Trees show that males are affected and not the females. Tree showing inheritance pattern of hemophilia a. Prominent linked to the royal british family. Believed that queen victoria was a carrier and had that gene: gene was passed onto children and children married different families in european houses (different royal family) When have hemophilia, when you get wounded = lose a a lot of blood.
