Biology 2581B Lecture Notes - Lecture 10: Cystic Fibrosis, Centimorgan, Genomic Library
20 Feb 2017
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Positional cloning finding a gene sequence based on its phenotype. Can be done with and without mapping information. If you do it without mapping information you need some other information. Did not know where this particular gene was located. Hemophilia a is linked to a gene that caused color blindness. A lot of times when someone had hemophilia a, they were also color blind. Hemophilia b trees indicated those 2 phenotypes could segregate independently from each other. Hemophilia a was caused by a different gene compared to. Hemophilia b and only hemophilia a was linked to color blindness. Hemophilia a was carried in the british royal family. Queen victoria was a carrier of the disease and passed it on to a number of her children. Carrier if you"re female; someone who potentially displays the phenotype if you"re male. Hemophilia a went through the whole royal family of europe when british royal family married off a particular son/daiughter with the disease.
