Biology 2581B Lecture Notes - Lecture 8: Null Allele, Frameshift Mutation, Arabidopsis Thaliana
20 Feb 2017
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Based on origin: spontaneous vs induced. Based on molecular change: base substitution insertion, deletion etc. Silent mutation change in sequence does not cause amino acid substitution: replace a with c, each amino acid is encoded by 1 to 6 codons. Gca and gcc both code for alanine. Put anything in wobble position and it still codes for the same amino acid sequence: some codons are strictly used for coding single amino acids e. g. methionine. Missense mutation mutations in 1st and 2nd position that change the amino acid: severity of effect: depends on what substitution and where. There are different types of aa and some of them are similar. Change an aa to a similar aa = no consequences for protein function. Change a polar aa to a non-polar one = consequences for protein function. Esp. if change happens in the catalytic site/somewhere that is critical for protein function.
