Biology 2581B Lecture Notes - Lecture 16: Methylation, Encode, Archaea
22 Apr 2017
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Lecture 16: more on encode & genetic modifications. Hgp sequenced the human genome, and it also annotated all the genes. Encode"s goal was not to look at the genes, but to look at all the functional bits found outside the coding regions. They found a lot of regulatory bits: transcriptor binding sites,enhancers, promoters. This seems counterintuitive because only 2% of the human genome is coding. Found that 80% of the human genome is involved with at least one biochemical function. In short, 80% of the human genome is functional: this goes against what we said previously about 90% of the genome being non-functional. There was a debate over the definition of the word function : encode described function as: anything that"s transcribed. Genomes often have a lot of transcriptional noise: things get transcribed all the time, even if they don"t code for anything: turns into rna, then probably gets deteriorated or something, genetics isn"t clean.
