Biology 1001A Lecture Notes - Blood Pressure, Selective Sweep, Pleiotropy
3 Dec 2012
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Selection should favor alleles that increase reproduction early in life, even at the expense of reproduction or survival late in life. Indy (i am not dead yet) mutants outlive wild type drosophila, but produce fewer offspring. No because people reproduce before getting cancer. Result: energy channeled into early reproduction, not repair. To steer their evolution, change their ecology. Different selective pressures than in the past historical constraints. The body is a bundle of compromises/trade offs. Selection acts on life time reproductive success, not on health, happiness or longevity. Weaker natural selection, due to medical advances. About 10 million children still die before reaching the age of reproduction. Weaker sexual selection, due to increased monogamy. Fewer mutations, due to decreasing reproduction by old men (less contribution to gene pool) 29 year old male has 300 cell divisions. 50 year old male has more than 1000 cell divisions. Average paternal age at reproduction is decreasing. Human populations are huge and super connected.
