Biology 1001A Lecture Notes - Lecture 3: Intron, Oncogene, Regulatory Sequence
10 Jan 2016
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Inversion (copy number variations) - sequence is flipped before it"s put back into a chromosome. Translocation: an enzyme can replicate part of one chromosome on the end of another chromosome if both are broken (burkitt lymphoma occurs when the c- myc gene from chromosome 8 is moved to chromosome 14) Insertion role of uv, ionizing radiation and ros in mutagenesis (ros = reactive oxygen species) These rays can directly break the dna backbone. Uv can cause thymine dimers to be created, therefore uv can only affect in locations where two thymines are beside each other. Exonuclease activity: dna polymerase has the ability to proofread its work. Sometimes rare errors can arise from dna polymerase called base-pair mismatches, but are corrected by dna repair mechanisms by dna polymerase. Doesn"t dna polymerase use deoxyribose nuclease (dnases cut, or cleave, only residues at the ends of dna molecules (exodeoxyribonuclease, a type of exonuclease).
