Biology 1001A Lecture Notes - Lecture 7: Enol, Tautomer, Thymine
10 May 2016
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Document Summary
Suppose that dna replication errors result in an a:t base pair being replaced by a g:c base pair. Yes, a doubled-stranded change in a sequence is a mutation. How much human variation is there? (*do not have to remember any of these numbers) Vast majority of variants are snps (most common variation) About 2500 structural variations including mobile elements, cnv, inversions, etc. About 100 variants are de novo new. We have mutations that were not inherited from parents. Bacterial elements code for their own mobility (transposase) There are sequences of dna that are mobile; they code for their own mobility. The simplest sequences in bacteria insertion sequences they code for an enzyme called transposase which enables this element to move from one location in the genome to the other location in the same genome. Two insertion sequences near together, they can move everything in between them. Transposons are associated with drug resistance in bacteria.
