Biology 1002B Lecture Notes - Lecture 7: Secretion, Signal Peptide, Cell Membrane
1 Feb 2017
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This is also how lipids can to the plasma membrane, lipids in bilayer also need to be constantly replaced. Relationship of fluidity to membrane functions, such as transport. All membranes should have the viscosity of vegetable oil. Proteins sit in membrane, some of these proteins need to change conformation to function. If the membrane is too rigid, the conformations can never change, and transporting will not be ef cient. Membrane uidity cannot be fully saturated, b/c then proteins wouldn"t be able to change conformation. Ex: channelrhodopsin is a protein that sits on membrane. If membrane is too rigid, then channelrhodopsin cannot change conformation, and function cannot be carried out. All fa"s are synthesized in saturated form (all single bonds) Degree of unsaturation (double bonds) is dictated by enzyme disaturases, they introduce double bonds. Membrane uidity can be modulated by modulating activity of desaturases. Each variation of desaturases catalyze a double bond at a different location.
