Dna (information) is relatively stable and readily replicated. We looked at the role of epigenetics in cancer but mutation plays a role in cancer as well. Many mutation mechanisms are involved with dna replication. Allows for accurate replication (a t, c g) There is always a new strand and an old strand after replication is complete. One circular genome creates one replication bubble and continues in both directions until complete. More dna to replicate, therefore they have more replication bubbles . Textbook gives the idea that the replicated strands are replicated in different places, but they are actually made by the same replication enzyme. You must present a properly paired base! Incoming nucleotides are added to the 3" oh of a properly paired previous base. Because of this rule it"s the only way to extend! Clicker (x3) polymerase can only do one thing extend the 3" end of dna.