Biology 1002B Lecture Notes - Lecture 17: Programmed Cell Death, Mental Floss, Histone Deacetylase
12 Mar 2016
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Helix-turn-helix - part of protein that interact with dna (not on part of protein that dna binds to) Maternal effect genes- transcribed in mother then mrna packed into egg (bicoid, ,etc) -not in nucleus. Epigenetic regulation - durable change in genome but does not cause mutation and persists beyond original stimulus that causes it and can last for cell generations. Methylation of dna can directly interfere with binding of transcription factors and attract hdac (histone de-acetylate) Removing acetylates shuts down aces to the promoter. Classic phenotypes of cancer cells - known for a long time. Nixon declared war on cancer - but nothing happened. Difference in diet, different carcinogens in environment, ethnicity (different genetic variations) Higher mortality for men than woman - still most common fatal disease. Sex specific hormone stimulation (lung and colon cancer = environmental) while (prostate breast cancer = genetic)
