Biology 1002B Lecture Notes - Lecture 17: Apoptosis, Oncogene, Zygote
11 Apr 2016
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8. 5a cell fusion experiments and studies of yeast mutants ideniied molecules that control the cell cycle. Discovered that all eukaryoic cells have counterparts of the yeast cdc2 gene, implying that this gene originated early during eukaryoic evoluion. Protein product of cdc2 is a protein kinase, an enzyme that catalyzes the phosphorylaion of a target protein: recall: phosphorylaion of proteins by protein kinases can acivate/inacivate proteins. 8. 5b the cell cycle can be arrested at speciic checkpoints. Cell has internal controls that monitor its progression through the cell through the acion of a set of control proteins called cyclins and cyclin-dependent kinases (cdks) Cdks are present throughout the cell cycle, but are acive only when complexed with cyclin. Each cyclin is synthesized/degraded in a way so that it is present only for a paricular phase of the cell cycle. 8. 5c cyclins and cyclin-dependent kinases are the internal controls that directly regulate.
