Biology 1201A Lecture Notes - Lecture 7: Wicket-Keeper, Caesium, Chromosome

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Role of tautomeric shifts in mutagenesis and mechanism of substitution mutagenesis during dna replication. A and g are purines, while t and c are pyrimidines. A"s (keto) bond with t"s (amino) forms 2 hydrogen bonds as usual and g"s (keto) with. C"s (amino) forms 3 hydrogen bonds as usual; because these bases are stable in a particular tautomeric form. However, when t bonds with g, t is in it"s enol form, and forms 3 bonds. When c is in it"s imino form it bonds with a, which is in its amino form. Adenine in it"s enol tautomeric form still calls a pyrimidine, it can not call another a, will call cytosine. Replicating your dna is mutagenic and creates mutations. Genetic variations arises out of the inherent stability of the biochemistry of dna mutations arise spontaneously out of the inherent instability of the stuff of dna snp"s can not be prevented. Certain chemicals like 5- bromouracil that are incorporated into are.

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