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Biology 1202B Lecture Notes - Lecture 14: Pyruvate Dehydrogenase Kinase, Atp Synthase, Anaerobic Respiration

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School
Western University
Department
Biology
Course
Biology 1202B
Professor
Tom Haffie

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Document Summary

If there is no oxygen, the pyruvate will go through fermentation, to rescue glycolysis. and if there is oxygen, then it will go to the mitochondria to make acetyl coa. Important enzyme that you need to know: pyruvate dehydrogenase kinase turns pyruvate into acetyl coa: hif-1 tells the p(cid:455)ru(cid:448)ate (cid:449)eather it should or should(cid:374)"t go i(cid:374)to the (cid:373)ito(cid:272)ho(cid:374)dria. Lactic acid fermentation: the nad+/nadh ratio will be low if the cell is hypoxic. How does the cell sense low oxygen: the sensor is a transpiration factor made up of hif-1 (in cytoplasm, always there and being expressed) and hif-1 (in the nucleus) If there is no oxygen, then the will go to the nucleus and come together with to make hif-1, which will regulate 100+ proteins, including pyruvate dehydrogenase kinase. Blood vessels around the tumor are limited, so the cancer cells secrete vegf, which will stimulate the growth of new blood vessels out of old ones.

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Related Questions

Multiple Choice

1. Which of the following describes lipids?

a source of nutrients for organisms 


energy-storage molecules 


molecules having structural role in membranes 


molecules that are part of hormones and pigments 


all of the above 


2. Molecules bearing both polar and nonpolar groups are said to be which of the following?

a. hydrophilic


b. amphipathic

c. hydrophobic

d. polyfunctional

3. By definition, carbohydrates contain which elements?

carbon and hydrogen 


carbon, hydrogen, and nitrogen 


carbon, hydrogen, and oxygen 


carbon and oxygen 


4. Monosaccharides may link together to form polysaccharides by forming which type of bond?

a. hydrogen

b. peptide


c. ionic


d. glycosidic

5. Which of the following is the name for molecules whose structures are nonsuperimposable mirror images?

structural isomers 


monomers 


polymers 


enantiomers 


Which of the following is an organism that obtains its energy from the transfer of electrons originating from chemical compounds and its carbon from an inorganic source?

a. chemoautotroph

b. chemoheterotroph

c. photoheterotroph

d. photoautotroph

7. A cell might perform anaerobic respiration for which of the following reasons?

It lacks glucose for degradation. 


It lacks the transition reaction to convert 
pyruvate to acetyl-CoA. 


It lacks Krebs cycle enzymes for processing 
acetyl-CoA to CO2. 


It lacks a cytochrome oxidase for passing 
electrons to oxygen. 


8. Which of the following is not an electron carrier within an electron transport system?

a. flavoprotein

b. ATP synthase

c. ubiquinone

d. cytochrome oxidase

9. Which of the following is the purpose of fermentation?

a. to make ATP

b. to make carbon molecule intermediates for anabolism

c. to make NADH

d. to make NAD+

10. Which of the following processes produces hydrogen sulfide?

anoxygenic photosynthesis 


oxygenic photosynthesis 


anaerobic respiration 


chemoautrophy 


11. In which growth phase would you observe the most endospores in a Bacillus cell culture?

death phase 


lag phase 


log phase 


log, lag, and death phases would all have roughly 
the same number of endospores. 


12. Which of the following is the best definition of generation time in a bacterium?

a. the length of time it takes to reach the log phase 


b. the length of time it takes for a population of 
cells to double 


c. the time it takes to reach stationary phase 


the length of time of the exponential phase 


If a culture starts with 50 cells, how many cells will be present after five generations with no cell death?

a. 200

b. 400

c. 1600

d. 3200

14. During which phase would penicillin, an antibiotic that inhibits cell-wall synthesis, be most effective?

death phase 


lag phase 


log phase 


stationary phase 


15. Pseudomonas aeruginosa is a common pathogen that infects the airways of patients with cystic fibrosis. It does not grow in the absence of oxygen. The bacterium is probably which of the following?

an aerotolerant anaerobe 


an obligate aerobe 


an obligate anaerobe 


a facultative anaerobe 


16. Which of the following refers to photosynthesis performed by bacteria with the use of water as the donor of electrons?

a. oxygenic


b. anoxygenic

c. heterotrophic

d. phototrophic

17. Which term best describes the relationship between pathogenic bacteria and humans?
A. amensalism

B. commensalism

C. parasitism

D. predation

18. Which describes bacteria that require low concentrations of oxygen to survive (less than that in the current atmosphere)?

A. facultative anaerobes

B. microaerophiles

C. obligate aerobes

D. obligate anaerobes

19. Cyanobacteria produce which of the following?

A. hydrogen sulfide gas
B. large quantities of ammonia

C. oxygen*
D. sulfuric acid

20.How do Archaea differ from Bacteria?

A. Archaea are found exclusively in extreme habitats.
B. Archaea have ether linkages in their cell membranes.*

C. Archaea have peptidoglycan cell walls.

D. Archaea lack a nucleus.

1. C6H12O6 + 6O2 Ã 6CO2 + 6H2O Glucose is being _____ to _____ and oxygen is being _____ to _____. a. oxidized; carbon dioxide; reduced; water b. oxidized; water; reduced; carbon dioxide Incorrect c. reduced; water; oxidized; carbon dioxide d. reduced; carbon dioxide; oxidized; water

2. Which of the following stages in the breakdown of the piece of toast you had for breakfast generates the most ATP? a. the citric acid cycle Incorrect b. glycolysis c. the digestion of starch to glucose d. oxidative phosphorylation

3. Which of the following is a catabolic pathway? a. gluconeogenesis b. production of starch Incorrect c. glycolysis d. production of glycogen

4. Per molecule, the oxidation of a fatty acid results in _____ energy storage than the oxidation of glucose. a. the same b. less Incorrect c. more d. None of the above; fatty acids cannot be oxidized.

5. Of the eight reactions in the citric acid cycle, how many are oxidation-reduction reactions? a. one b. two c. three d. four e. five

6. The process of glycolysis transfers the energy in sugar molecules into the stored energy of activated carriers such as ATP and NADH. Which statement is true about glycolysis? a. Only eukaryotic organisms do glycolysis. b. The ten reactions of glycolysis are identical in all eukaryotic cells, but are different in prokaryotic cells due to their diverse metabolic strategies. Incorrect c. The ten reactions of glycolysis are identical in almost all living organisms on the planet. d. There are many ways to oxidize glucose and transfer energy into activated carriers; the diversity of organisms on the planet is reflected in the diversity of their mechanisms of glycolysis.

7. Referring to the sentence completed in #13 above, the purpose of the latter reaction (in active muscle cells) is to _____. a. accumulate lactic acid in the cell, which provides additional energy for the production of ATP Incorrect b. slow down glycolysis until oxygen becomes available again c. accelerate the Krebs cycle, which will restore the oxygen supply d. regenerate NAD+ so that glycolysis can continue in the absence of oxygen

8. What are the products of the citric acid cycle? a. carbon dioxide, NADH, FADH2 and GTP b. carbon dioxide, NAD+, FAD and GTP c. NADH, FADH2, and acetyl CoA Incorrect d. carbon dioxide and water

9. Which statement is true about enzymes? a. Enzymes catalyze chemical reactions because they make inherently endergonic reactions exergonic. b. Each enzyme in a cell can catalyze many different chemical reactions involving chemically different substrates. Incorrect c. Enzymes can only catalyze reactions in one direction. d. After catalyzing a reaction, an enzyme is permanently altered and can no longer bind substrate. e. None of the above is true. 1

10. ∆G measures the change in free energy in a system as it converts reactant (Y) into product (X). When [X] = [Y], ∆G is equal to _____. a. RT b. ΔG° + RT c. ΔG° d. ln [X]/[Y]

11. The ∆G° for the hydrolysis of ATP is -7.3 kcal/mol. What conditions in the cell would lead to a ∆G for ATP hydrolysis of -11 kcal/mol? a. An increase in the ATP/ADP ratio b. An increase in anabolic activity in the cell c. Transport of ATP out of the compartment where the reaction is occurring Incorrect d. A decrease in the ATP/ADP ratio

12. In the first reaction of glycolysis, a phosphate transferred from ATP to a glucose molecule to produce glucose-6-phosphate and ADP. Under conditions existing in the cell, the free energy change for this reaction is -8.0 kcal/mole. Which of the following statements is true? Recall that the ∆G° for the hydrolysis of ATP is -7.3 kcal/mol. a. Glucose concentrations in the cell are always low, making this reaction more favorable than would be expected. b. This reaction is less favorable than would be expected, given the ∆G° of ATP hydrolysis. c. Glucose-6-P concentrations in the cell are very low relative to glucose concentrations, making the reaction more favorable than would be expected. d. The ∆G° for the addition of a phosphate to glucose must be -0.7 kcal/mole.

13. Protein E can bind to two different proteins, S and I. The binding reactions are described by the following equations and values: E + S --> ES Keq for ES = 10 E + I> EI Keq for EI = 2 Given the equilibrium constant values, which one of the following statements is true? a. When S is present in excess, no I molecules will bind to E. b. E binds I more tightly than S. c. The binding energy of the ES interaction is greater than that of the EI interaction. d. Changing an amino acid on the binding surface of I from a basic amino acid to an acidic one will probably make the free energy of association with E more negative.