Biology 3597A/B Lecture Notes - Lecture 8: Tata-Binding Protein, Peptide, Stem-Loop
6 Feb 2017
School
Department
Course
Professor
Document Summary
We know less about euks than proks and what we do know its mostly the simple euks. ** slide transcriptional attenuation control by rna folding. R(cid:374)a pol does(cid:374)"t stop, the (cid:396)i(cid:271)oso(cid:373)e does error. All protein coding genes will have same general/basal transcription machinery. Sequence specific dna binding proteins transcription factors. Coactivators and corepressors do(cid:374)"t a(cid:272)tually (cid:271)i(cid:374)d dna (cid:271)ut (cid:396)egulate intermediates may bind other proteins and that has an action, or bind a protein and may recruit another protein. Rna pol 2 adds nt to growing chain and proofreads. General tfs involved in transcriptional initiation, recognition of promoter, initial unwinding and then vast majority of tfs lost (most involved in initiation, some go to elongation) Do(cid:374)"t (cid:374)eed to k(cid:374)o(cid:449) (cid:449)hat su(cid:271)u(cid:374)its do, just k(cid:374)ow that 4 and 7 differ strucutrelaly stick out of polymerase help guide/identify to dna elements, or tfs. Cleft dna/rna hybrid goes through and clamped on either side.
